Quality Control of tert-Butyl carbamateIn 2020 ,《Highly Enantioselective Synthesis of Propargyl Amide with Vicinal Stereocenters through Ir-Catalyzed Hydroalkynylation》 appeared in Angewandte Chemie, International Edition. The author of the article were Zhang, Wen-Wen; Zhang, Su-Lei; Li, Bi-Jie. The article conveys some information:
Chiral propargyl amines are valuable synthetic intermediates for the preparation of biol. active compounds and functionalized amines. Catalytic methods to access propargyl amines containing vicinal stereocenters with high diastereoselectivity are particularly rare. The authors report an unprecedented strategy for the synthesis of enantioenriched propargyl amines with two stereogenic centers. An iridium complex, ligated by a phosphoramidite ligand, catalyzes the hydroalkynylation of β,β-disubstituted enamides to afford propargyl amides in a highly regio-, diastereo-, and enantioselective fashion. Stereodivergent synthesis of all four possible stereoisomers was achieved using this strategy.tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate) was used in this study.
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Quality Control of tert-Butyl carbamate
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