Safety of Diethyl 2-methylmalonateIn 2021 ,《An Alkyne-Metathesis-Based Approach to the Synthesis of the Anti-Malarial Macrodiolide Samroiyotmycin A》 was published in Angewandte Chemie, International Edition. The article was written by Yiannakas, Ektoras; Grimes, Mark I.; Whitelegge, James T.; Fuerstner, Alois; Hulme, Alison N.. The article contains the following contents:
The authors report the first total synthesis of samroiyotmycin A (I), a C2-sym. 20-membered anti-malarial macrodiolide isolated from Streptomyces sp. The convergent synthetic strategy orchestrates bisalkyne fragment-assembly using an unprecedented Schollkopf-type condensation on substituted β-lactone II and an ambitious late-stage one-pot alkyne cross metathesis-ring-closing metathesis (ACM-RCAM) reaction. The demanding alkyne metathesis sequence is achieved using the latest generation of molybdenum alkylidynes endowed with a tripodal silanolate ligand framework. Subsequent conversion to the required E-alkenes uses contemporary hydrometallation chem. catalyzed by tetrameric cluster [{Cp*RuCl}4]. After reading the article, we found that the author used Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Safety of Diethyl 2-methylmalonate
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics