《Combined Theoretical and Experimental Studies Unravel Multiple Pathways to Convergent Asymmetric Hydrogenation of Enamides》 was written by Yang, Jianping; Massaro, Luca; Krajangsri, Suppachai; Singh, Thishana; Su, Hao; Silvi, Emanuele; Ponra, Sudipta; Eriksson, Lars; Ahlquist, Maarten S. G.; Andersson, Pher G.. Recommanded Product: 4755-77-5This research focused onvinyl oxazolidinone iridium catalyst enantioselective asym hydrogenation reaction; ethyl oxazolidinone preparation. The article conveys some information:
A highly efficient convergent asym. hydrogenation of E/Z mixtures of enamides catalyzed by N,P-iridium complexes supported by mechanistic studies was reported. It was found that reduction of the olefinic isomers (E and Z geometries) produced chiral amides with the same absolute configuration (enantioconvergent hydrogenation). This allowed the hydrogenation of a wide range of E/Z mixtures of trisubstituted enamides with excellent enantioselectivity (up to 99% ee). A detailed mechanistic study using deuterium labeling and kinetic experiments revealed two different pathways for the observed enantioconvergence. For α-aryl enamides, fast isomerization of the double bond took place, and the overall process resulted in kinetic resolution of the two isomers. For α-alkyl enamides, no double bond isomerization was detected, and competition experiments suggested that substrate chelation was responsible for the enantioconvergent stereochem. outcome. DFT calculations were performed to predict the correct absolute configuration of the products and strengthen the proposed mechanism of the iridium-catalyzed isomerization pathway. After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 4755-77-5
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics