Name: N-Boc-1,6-DiaminohexaneIn 2021 ,《Discovery of a PROTAC targeting ALK with in vivo activity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yan, Guoyi; Zhong, Xinxin; Yue, Lin; Pu, Chunlan; Shan, Huifang; Lan, Suke; Zhou, Meng; Hou, Xueyan; Yang, Jie; Li, Rui. The article conveys some information:
Anaplastic lymphoma kinase (ALK) was involved in the development of various cancer types. Although several ALK inhibitors have been advanced to clin. trials, the emergence of drug resistance has limited the clin. application of them. To overcome the drug resistance, proteolysis targeting chimeras (PROTACs) could be an alternative strategy. In this study, a series of ALK degraders were designed and synthesized. The degraders were developed through the conjugation of LDK378 and CRBN E3 ubiquitin ligase ligands. Among all the mols., compound I showed potent selective inhibitory activity to ALK and can decrease the cellular levels of ALK fusion proteins in a concentration- and time-dependent manner in H3122 cell line. Meanwhile, I showed improved anticancer activity in vitro comparing with LDK378 and the antiproliferative activity to xenograft tumor model was acceptable. All the results demonstrated that ALK degrader I with in vitro and in vivo anti-cancer activities was valuable for further investigation. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Name: N-Boc-1,6-Diaminohexane)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Name: N-Boc-1,6-Diaminohexane
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