COA of Formula: C6H10O3On September 22, 2021 ,《Enantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction》 was published in Journal of the American Chemical Society. The article was written by Wang, Xiao-Mei; Zhang, Peng; Xu, Qi; Guo, Chang-Qiu; Zhang, De-Bing; Lu, Chuan-Jun; Liu, Ren-Rong. The article contains the following contents:
Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction is described. A wide range of axially chiral N-N bisazaheterocycle compounds were efficiently prepared in high yields with excellent enantioselectivities via desymmetrization and kinetic resolution Heating experiments showed that the axially chiral bisazaheterocycle products have high rotational barriers. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0COA of Formula: C6H10O3)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.COA of Formula: C6H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics