Computed Properties of C10H22N2O2In 2018 ,《Two-step activity-based protein profiling of diacylglycerol lipase》 appeared in Organic & Biomolecular Chemistry. The author of the article were van Rooden, Eva J.; Kreekel, Roy; Hansen, Thomas; Janssen, Antonius P. A.; van Esbroeck, Annelot C. M.; den Dulk, Hans; van den Berg, Richard J. B. H. N.; Codee, Jeroen D. C.; van der Stelt, Mario. The article conveys some information:
Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release. Chem. tools that visualize endogenous DAGL activity are desired. Here, we report the design, synthesis and application of a triazole urea probe for DAGL equipped with a norbornene as a biorthogonal handle. The activity and selectivity of the probe was assessed with activity-based protein profiling. This probe was potent against endogenous DAGLα (IC50 = 5 nM) and it was successfully applied as a two-step activity-based probe for labeling of DAGLα using an inverse electron-demand Diels-Alder ligation in living cells. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Computed Properties of C10H22N2O2)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Computed Properties of C10H22N2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics