《Pd(II)-Catalyzed Synthesis of Bicyclo[3.2.1] Lactones via Tandem Intramolecular β-C(sp3)-H Olefination and Lactonization of Free Carboxylic Acids》 was written by Tomanik, Martin; Qian, Shaoqun; Yu, Jin-Quan. Safety of Benzyl acrylateThis research focused onunsaturated carboxylic acid palladium catalyst tandem olefination lactonization; bicyclo lactone preparation. The article conveys some information:
Herein, the detail development of a novel palladium(II)-catalyzed tandem intramol. β-C(sp3)-H olefination and lactonization reaction that rapidly transforms linear carboxylic acid possessing a tethered olefin into the bicyclo[3.2.1] lactone motif was reported. This transformation features a broad substrate scope, shows excellent functional group compatibility, and was extended to the preparation of the related seven-membered bicyclo[4.2.1] lactones. Addnl., the synthetic potential of this annulation by constructing the 6,6,5-tricyclic lactone core structure of the meroterpenoid cochlactone A was demonstrated. It was anticipated that this compelling reaction may provide a novel synthetic disconnection that can be broadly applied toward the preparation of a variety of bioactive natural products. In the experiment, the researchers used many compounds, for example, Benzyl acrylate(cas: 2495-35-4Safety of Benzyl acrylate)
Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Safety of Benzyl acrylate
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