In 2022,Tian, Caizhi; Huang, Shuoqi; Xu, Zihua; Liu, Wenwu; Li, Deping; Liu, Mingyue; Zhu, Chengze; Wu, Limeng; Jiang, Xiaowen; Ding, Huaiwei; Zhao, Qingchun published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects》.Related Products of 7524-52-9 The author mentioned the following in the article:
A series of novel β-carboline 1,3,4-oxadiazole based hybrids were designed, synthesized, and tested for cytotoxicity and HDAC inhibition. Among the target compounds, compound I displayed high inhibitory activity for class I HDACs 1, 2, and 3, and potent anti-proliferative activity against HCT116 cells with an IC50 value of 0.173 ± 0.018μM, it also exhibited better inhibitory activity with an IC50 value of 6 nM for HDAC6 than SAHA (IC50 = 15 nM). Furthermore, the pharmacol. experiment of Hoechst staining, colony formation, cell apoptosis assay, and wound healing scratch assay indicated that compound I was a potent cytotoxic agent against HCT116 cells with cell apoptosis induction. Further, in silico prediction of physicochem. properties, drug-likeness, and ADME parameters suggested that compound I is a promising anticancer agent. Taken together, the high potency cytotoxicity and class I HDACs inhibitory activity of compound I, which with the β-carboline 1,3,4-oxadiazole based hybrids as potent anticancer agents could be nominated for further modification and optimization. The results came from multiple reactions, including the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Related Products of 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Related Products of 7524-52-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics