《Two Scalable Syntheses of 3-(Trifluoromethyl)cyclobutane-1-carboxylic Acid》 was written by Song, Zhiguo J.; Qi, Ji; Emmert, Marion H.; Wang, Jinxing; Yang, Xuezhi; Xiao, Dong. Quality Control of Ethyl oxalyl monochlorideThis research focused ontrifluoromethylcyclobutane carboxylic acid preparation scalable. The article conveys some information:
Two efficient synthetic methods for preparation of 3-(trifluoromethyl)cyclobutane-1-carboxylic acid are reported starting from readily available 4-oxocyclobutane precursors. These cyclobutanones can be converted to their CF3 carbinols upon treatment with TMSCF3 and a fluoride source. The bis-carboxylate system was deoxygenated by treatment of Bu3SnH and provided desired compound 3-(trifluoromethyl)cyclobutane-1-carboxylic acid upon decarboxylation. In the monocarboxylate system, the triflate could be efficiently eliminated; subsequent hydrogenation afforded cis-3-(trifluoromethyl)cyclobutane-1-carboxylic acid. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Quality Control of Ethyl oxalyl monochloride) was used in this study.
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Quality Control of Ethyl oxalyl monochloride
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