Shan, Huifang; Ma, Xinyu; Yan, Guoyi; Luo, Meng; Zhong, Xinxin; Lan, Suke; Yang, Jie; Liu, Yuanyuan; Pu, Chunlan; Tong, Yu; Li, Rui published an article in 2021. The article was titled 《Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold》, and you may find the article in European Journal of Medicinal Chemistry.Electric Literature of C11H24N2O2 The information in the text is summarized as follows:
Cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in dynamic regulation of cell cycle, play an indispensable role in controlling the tumor growth. Here, based on the scaffold of palbociclib, we designed and synthesized a series of covalent CDK4/6 inhibitors that targeted amino acid Thr107. The optimized compound C-13(I) exhibited potent in vitro anticancer activity against CDK4/6 with high selectivity over CDK4/6. Moreover, C-13 showed significant tumor growth inhibition in MDA-MB-231 tumor xenograft model (TGI of 93.49% at dose of 40 mg/kg) without causing significant weight loss and toxicity during the treatment period. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Electric Literature of C11H24N2O2)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsElectric Literature of C11H24N2O2
Referemce:
Ester – Wikipedia,
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