Ruiz-Santaquiteria, Marta; Illescas, Beatriz M.; Abdelnabi, Rana; Boonen, Arnaud; Mills, Alberto; Marti-Mari, Olaia; Noppen, Sam; Neyts, Johan; Schols, Dominique; Gago, Federico; San-Felix, Ana; Camarasa, Maria-Jose; Martin, Nazario published an article in 2021. The article was titled 《Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors》, and you may find the article in Chemistry – A European Journal.HPLC of Formula: 7524-52-9 The information in the text is summarized as follows:
Unprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity of these novel compounds against HIV and EV71 reveal that they are much more potent against HIV and equally active against EV71 than the previously described dendrimer prototypes AL-385 and AL-463, which possess the same number of Trp/Tyr residues on the periphery but attached to a smaller and more flexible pentaerythritol core. These results demonstrate the relevance of the globular 3D presentation of the peripheral groups (Trp/Tyr) as well as the length of the spacer connecting them to the central core to interact with the viral envelopes, particularly in the case of HIV, and support the hypothesis that [60]fullerene can be an alternative and attractive biocompatible carbon-based scaffold for this type of highly sym. dendrimers. In addition, the functionalized fullerenes here described, which display twelve peripheral neg. charged indole moieties on their globular surface, define a new and versatile class of compounds with a promising potential in biomedical applications. The experimental process involved the reaction of H-Trp-OMe.HCl(cas: 7524-52-9HPLC of Formula: 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.HPLC of Formula: 7524-52-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics