《3D-Printed Polypropylene Continuous-Flow Column Reactors: Exploration of Reactor Utility in SNAr Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles》 was written by Rao, Zenobia X.; Patel, Bhaven; Monaco, Alessandra; Cao, Zi Jing; Barniol-Xicota, Marta; Pichon, Enora; Ladlow, Mark; Hilton, Stephen T.. Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateThis research focused onthree dimensional printed polypropylene continuous flow reactor; bicyclic tetracyclic heterocycle preparation. The article conveys some information:
3D printing has the potential to transform the way in which chem. reactions are carried out due to its low-cost, ease-of-use as a technol. and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low-cost polypropylene (PP) column reactor that was incorporated into an existing continuous-flow reactor for the synthesis of heterocycles. The utility and solvent resistance of the printed devices were explored in SNAr reactions to produce substituted aniline derivatives and in the synthesis of bicyclic and tetracyclic heterocycles. Using this approach, a range of heterocyclic compounds was synthesized including the core structure of the natural product (±)-γ-lycorane and structurally complex compounds based on the tetracyclic core of the erythrina alkaloids. The results came from multiple reactions, including the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate
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