《Studies towards the Total Synthesis of Drimentine C. Preparation of the AB and CDEF Ring Fragments》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Pound, Sarah M.; Underwood, Steven J.; Douglas, Christopher J.. Quality Control of H-Trp-OMe.HCl The article mentions the following:
The drimentine family is a class of hybrid isoprenoids derived from actinomycete bacteria. Members of this family display weak antitumor and antibacterial activity. Herein we report our efforts toward the total synthesis of drimentine C (I) using three distinct approaches incorporating palladium-catalyzed cyanoamidation, reductive cross-coupling, and photoredox-catalyzed α-alkylation of an aldehyde as key steps. Our synthetic efforts use a convergent synthesis to assemble the terpenoid and alkaloid portions of drimentine C from readily available L-tryptophan, L-proline, and (+)-sclareolide. The experimental process involved the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Quality Control of H-Trp-OMe.HCl)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Quality Control of H-Trp-OMe.HCl
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