Piloto, Ana Margarida L.; Ribeiro, David S. M.; Rodrigues, S. Sofia M.; Santos, Joao L. M.; Sampaio, Paula; Sales, Maria Goreti Ferreira published the artcile< Cellulose-based hydrogel on quantum dots with molecularly imprinted polymers for the detection of CA19-9 protein cancer biomarker>, Computed Properties of 3290-92-4, the main research area is cancer biomarker CA19 9 cellulose hydrogel mol imprinted polymer; CA 19–9 protein; Imprinted cellulose hydrogels; Molecularly imprinted polymers; Optical sensor; Pancreatic cancer diagnosis; Quantum dots.
Molecularly imprinted polymers MIPs were successfully assembled around quantum dots (QDs), for the detection of the protein biomarker CA19-9 associated to pancreatic cancer (PC). These imprinted materials MIP@QDs were incorporated within the cellulose hydrogel with retention of its conformational structure inside the binding cavities. The concept is to use MIPs which function as the biorecognition elements, conjugated to cadmium telluride QDs as the sensing system. The excitation wavelength was set to 477 nm and the fluorescence signal was measured at its maximum intensity, with an emission range between 530 and 780 nm. The fluorescence quenching of the imprinted cellulose hydrogels occurred with increasing concentrations of CA19-9, showing linearity in the range 2.76 x 10 -2 – 5.23 x 10 2 U/mL, in a 1000-fold diluted human serum. Replicates of the imprinted hydrogel show a linear response below the cut-off values for pancreatic cancer diagnosis (< 23 U/mL), a limit of detection of 1.58 x 10 -3 U/mL and an imprinting factor (IF) of 1.76. In addition to the fact that the imprinted cellulose hydrogel displays good stability and selectivity towards CA19-9 when compared with the non-imprinted controls, the conjugation of MIPs to QDs increases the sensitivity of the system for an optical detection method towards ranges within clin. significance. This fact shows potential for the imprinted hydrogel to be applied as a sensitive, low-cost format for point-of-care tests (PoCTs). Microchimica Acta published new progress about Adsorption. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Computed Properties of 3290-92-4.
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