Petti, Alessia; Fagnan, Corentin; van Melis, Carlo G. W.; Tanbouza, Nour; Garcia, Anthony D.; Mastrodonato, Andrea; Leech, Matthew C.; Goodall, Iain C. A.; Dobbs, Adrian P.; Ollevier, Thierry; Lam, Kevin published their research in Organic Process Research & Development in 2021. The article was titled 《Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates》.Quality Control of Ethyl oxalyl monochloride The article contains the following contents:
A new electrochem. supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. Simple, practical, and phosgene-free route includes the generation of an isocyanate intermediate in-situ via anodic decarboxylation of an oxamic acid in the presence of an organic base, followed by the one-pot addition of suitable nucleophiles to afford the corresponding ureas, carbamates, and thiocarbamates. This procedure was applicable to different amines, alcs., and thiols. Furthermore, when single-pass continuous electrochem. flow conditions were used and this reaction were run in a carbon graphite Cgr/Cgr flow cell, urea compounds was obtained in high yields within a residence time of 6 min, unlocking access to substrates that were inaccessible under batch conditions while being easily scalable. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Quality Control of Ethyl oxalyl monochloride)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Ethyl oxalyl monochloride
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