In 2022,Peng, Bingfei; Ma, Jiguo; Guo, Jianhua; Gong, Yating; Wang, Ronghao; Zhang, Yi; Zeng, Jinlong; Chen, Wen-Wen; Ding, Kuiling; Zhao, Baoguo published an article in Journal of the American Chemical Society. The title of the article was 《A Powerful Chiral Super Bronsted C-H Acid for Asymmetric Catalysis》.Quality Control of tert-Butyl carbamate The author mentioned the following in the article:
A new type of chiral super Bronsted C-H acids, BINOL-derived phosphoryl bis((trifluoromethyl)sulfonyl) methanes (BPTMs) I [R = Ph, 4-NO2C6H4, 1-naphthyl, etc.] were developed. As compared to widely utilized BINOL-derived chiral phosphoric acids (BPAs) and N-triflyl phosphoramides (NTPAs), BPTMs displayed much higher Bronsted acidity, resulting in dramatically improved activity and excellent enantioselectivity as demonstrated in catalytic asym. Mukaiyama-Mannich reaction, allylic amination, three-component coupling of allyltrimethylsilane with 9-fluorenylmethyl carbamate and aldehydes, and protonation of silyl enol ether. These new strong Bronsted C-H acids have provided a platform for expanding the chem. of asym. Bronsted acid catalysis. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Quality Control of tert-Butyl carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics