Ohuchida, Shuichi; Hamanaka, Nobuyuki; Hayashi, Masaki published the artcile< Synthesis of thromboxane A2 analogs: DL-9,11:11,12-dideoxa-9,11:11,12-diepithiothromboxane A2>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is thromboxane A2 analog; dideoxadiepithiothromboxane A2.
Thromboxane A2(TXA2), one of the major products formed from arachidonic acid, possesses powerful biol. effects, i.e., platelet aggregation and vasoconstriction. In spite of these very important biol. actions, this substance is too unstable to be isolated. Therefore synthesis of the stable TXA2 analogs with potent biol. activities is of great importance in thromboxane research. However, only a few stable analogs of TXA2 have been reported because of its chem. unusual structure. The total synthesis of the stable TXA2 analogs, dl-9,11:11,12-dideoxa-9,11:11,12-diepithiothromboxane A2 Me ester (I; R = Me) and the Na salt (I; R = Na), has been achieved starting from (MeO)2CHCOCH2CO2Me. The ester was converted to the key intermediate II in high yield, which was efficiently transformed into the precursor III leading to the main framework, 2,6-dithiabicyclo[3.1.1]heptane, via the compound IV. III was treated with base to afford the desired bicyclic product. The TXA2 analogs thus obtained showed very potent biol. activities.
Journal of the American Chemical Society published new progress about Blood platelet. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.
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