In 2022,Nural, Yahya; Ozdemir, Sadin; Yalcin, Mustafa Serkan; Demir, Bunyamin; Atabey, Hasan; Seferoglu, Zeynel; Ece, Abdulilah published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《New bis- and tetrakis-1,2,3-triazole derivatives: synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants》.Computed Properties of C5H6O2 The author mentioned the following in the article:
Series of bis- and tetrakis-1,2,3-triazole derivatives I (R = BrCH2CH2, 2-pentyl, cyclopropyl, cyclohexylmethyl, Ph, etc.) and II were synthesized using copper-catalyzed azide-alkyne cycloaddition click chem. in 73-95% yields. The bis- and tetrakis-1,2,3-triazoles exhibited significant DNA cleavage activity while the tetrakis-1,2,3-triazole analog II (R = Ph) completely degraded the plasmid DNA. Mol. docking simulations suggest that the compound II (R = Ph) acts as minor groove binder of DNA by binding through several noncovalent interactions with base pairs. All bis- and tetrakis-1,2,3-triazole derivatives were screened for antibacterial activity against E. coli, B. cereus, S. aureus, P. aeruginosa, E. hirae, L. pneumophila subsp. pneumophila strains and antifungal activity against microfungus C. albicans and C. tropicalis strains. The compound I (R = cyclohexylmethyl) exhibited the best antibacterial activity among bis-1,2,3-triazoles against E. coli and E. hirae, while II (R = cyclopentyl) exhibited the best antibacterial activity among tetrakis-1,2,3-triazoles against E. hirae. Furthermore, the best antifungal activity against C. albicans and C. tropicalis was reported for the compound I (R = N3CH2CH2), while II (R = cyclohexylmethyl) displayed the best antifungal activity against C. tropicalis and C. albicans. The reported data here conclude that the bis- and tetrakis-1,2,3-triazoles are important cores that should be considered for further development of new anticancer agents acting through the DNA cleavage activity. In the experiment, the researchers used many compounds, for example, Ethyl propiolate(cas: 623-47-2Computed Properties of C5H6O2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Computed Properties of C5H6O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics