《Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics》 was published in Journal of the American Chemical Society in 2020. These research results belong to Nicolaou, K. C.; Das, Dipendu; Lu, Yong; Rout, Subhrajit; Pitsinos, Emmanuel N.; Lyssikatos, Joseph; Schammel, Alexander; Sandoval, Joseph; Hammond, Mikhail; Aujay, Monette; Gavrilyuk, Julia. Recommanded Product: 4248-19-5 The article mentions the following:
The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-F and yangpumicin A. This family of natural products provides opportunities in total synthesis, biol., and medicine due to their novel and challenging mol. structures, intriguing biol. properties and mechanism of action, and potential in targeted cancer therapies. Herein, the total syntheses of tiancimycins A and B, yangpumicin A, and a number of related anthraquinone-fused enediynes are described. Biol. evaluation of the synthesized compounds revealed extremely potent cytotoxicities against a number of cell lines, thus enriching the structure-activity relationships within this class of compounds The findings of these studies may facilitate future investigations directed toward antibody-drug conjugates for targeted cancer therapies and provide inspiration for further advances in total synthesis and chem. biol.tert-Butyl carbamate(cas: 4248-19-5Recommanded Product: 4248-19-5) was used in this study.
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 4248-19-5
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Ester – an overview | ScienceDirect Topics