In 2019,Catalysis Science & Technology included an article by Mourelle-Insua, Angela; Mendez-Sanchez, Daniel; Galman, James L.; Slabu, Iustina; Turner, Nicholas J.; Gotor-Fernandez, Vicente; Lavandera, Ivan. Product Details of 30414-53-0. The article was titled 《Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions》. The information in the text is summarized as follows:
The biocatalytic stereocontrolled synthesis of various acyclic anti- or syn-α-alkyl-β-amino amides through a dynamic kinetic resolution strategy is demonstrated. A series of com. available and inhouse transaminases (TAs) were employed to perform the transamination of a series of chem. synthesized racemic α-alkyl-β-keto amides. Among them, com. (R)-selective TAs showed the best activities and selectivities, giving access preferentially to the anti-diastereoisomers with low to high diastereomeric ratios (up to 96%) and excellent enantiomeric excess (>99%). The stereoselective biotransamination experiments were successfully demonstrated at a semi-preparative scale (25 mM, 100 mg substrate), leading to the corresponding optically active α-alkyl-β-amino amides in 45-90% isolated yields after a simple liquid-liquid extraction protocol. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-oxovalerate(cas: 30414-53-0Product Details of 30414-53-0)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Product Details of 30414-53-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics