COA of Formula: C8H6FNO4In 2009 ,《Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Miyashiro, Julie; Woods, Keith W.; Park, Chang H.; Liu, Xuesong; Shi, Yan; Johnson, Eric F.; Bouska, Jennifer J.; Olson, Amanda M.; Luo, Yan; Fry, Elizabeth H.; Giranda, Vincent L.; Penning, Thomas D.. The article conveys some information:
Based on screening hit I, a series of tricyclic quinoxalinones e.g. II, have been designed and evaluated for inhibition of PARP-1. Substitutions at the 7- and 8-positions of the quinoxalinone ring led to a number of compounds with good enzymic and cellular potency. The tricyclic quinoxalinone class is sensitive to modifications of both the amine substituent and the tricyclic core. The synthesis and structure-activity relationship studies are presented. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9COA of Formula: C8H6FNO4)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.COA of Formula: C8H6FNO4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics