Miller, Max W.; Mylari, Banavara L.; Howes, Harold L. Jr.; Figdor, Sanford K.; Lynch, Martin J.; Lynch, John E.; Koch, Richard C. published the artcile< Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azauracil derivative preparation anticoccidial; sulfonamide azauracil anticoccidial; mol structure azauracilsulfonamide anticoccidial.
Sixty-three 1-phenyl-6-azauracils I (R and R1 = H, Cl, Me, or Br; X = SO2Cl, SO2NH2, morpholinosulfonyl, SO2NMe2, etc.) were synthesized and tested for anticoccidial activity. In contrast to previous 1-phenyl-6-azauracils, some I had high activity against Eimeria tenella infections in chickens with a very rapid rate of clearance from plasma. 1-[3′-Chloro-5′-methyl-4′-(morpholinylsulfonyl)phenyl]-6-azauracil [38571-62-9] was the most active compound, with a min. effective concentration in feed of ∼10 ppm. Structure-activity relations are discussed.
Journal of Medicinal Chemistry published new progress about Coccidiosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
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Ester – an overview | ScienceDirect Topics