Mecwan, Marvin M.; Dong, Xia; Shi, Galen H.; Ratner, Buddy D. published the artcile< Plasma Polymerized HMDSO Coatings For Syringes To Minimize Protein Adsorption>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is coating hexamethyldisiloxane plasma polymerization syringe protein adsorption IgG; Glass vials; HMDSO; Hypodermic syringes; IgG; Protein adsorption; Protein retention; RFGD plasma polymerization; Silicone oil.
Current parenteral containers used for the storage and delivery of protein-based drugs, contain silicone oil which may seep into the protein solution and can result in adsorption, aggregation and denaturation of the protein. Tightly adherent surface coatings prepared by radio frequency glow-discharge (RFGD) plasma polymerization are described in this paper. Using this robust technique, methacrylic acid (MA) (hydrophilic), hexamethyldisiloxane (HMDSO) (hydrophobic), tetraglyme (TG) (hydrophilic) were plasma polymerized onto glass. In addition, HMDSO and MA were copolymerized to create a plasma polymerized HMDSO-MA (hydrophobic) surface. Untreated glass and glass dip-coated in PDMS were used as controls. TG and MA plasma coatings adsorbed the least amount of protein in all pH conditions. Interestingly HMDSO-MA retained significantly lesser protein compared to HMDSO and dip-coated PDMS samples. In the presence of Polysorbate 80 (PS80) all plasma polymerized coatings adsorbed and retained negligible amounts of protein, compared to controls. Furthermore, the peak glide force of plasma coated syringes did not significantly increase compared to syringes without plasma coating. Due to the versatility of RFGD plasma, this process is scalable and could potentially be used for the treatment of hypodermic syringes used for the storage and delivery of protein-based therapeutics.
Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Adsorption (of proteins). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics