In 2013,Martin, Kevin S.; Soldi, Cristian; Candee, Kellan N.; Wettersten, Hiromi I.; Weiss, Robert H.; Shaw, Jared T. published 《From bead to flask: synthesis of a complex β-amido-amide for probe-development studies》.Beilstein Journal of Organic Chemistry published the findings.SDS of cas: 329-59-9 The information in the text is summarized as follows:
A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a one-bead, one-compound combinatorial approach for an on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related structures. The key step involves the use of a β-amino acid-forming three-component reaction (3CR), the scope of which defines its role in the synthetic strategy. The title compound thus formed was LLW62 (I) [2-[3-[4-(1,1-dimethylethyl)phenoxy]phenyl]-β-[[[(2-methylphenyl)amino]carbonyl]amino]-1-[3-(1-pyrrolidinyl)propyl]-1H-benzimidazole-5-propanamide]. The synthesis of the target compound was achieved by a multicomponent reaction of 4-fluorobenzaldehyde with propanedioic acid and ammonium acetate, thus forming β-amino-4-fluorobenzenepropanoic acid. After reading the article, we found that the author used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9SDS of cas: 329-59-9)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.SDS of cas: 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics