Manickam, Manoj; Boggu, Pulla Reddy; Pillaiyar, Thanigaimalai; Nam, Yeo Jin; Abdullah, Md.; Lee, Seung Jin; Kang, Jong Seong; Jung, Sang-Hun published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《Design, synthesis and anticancer activity of 2-amidomethoxy-1,4-naphthoquinones and its conjugates with Biotin/polyamine》.Synthetic Route of C11H24N2O2 The article contains the following contents:
In continuation with the previous work, a series of 5-hydroxy-2-amidomethoxy-1,4-naphthoquinones were prepared to establish the structure-activity relationship studies toward anticancer activity (IC50 in μM) against three cell lines; colo205 (colon adenocarcinoma), T47D (breast ductal carcinoma) and K562 (chronic myelogenous leukemia). Among the synthesized compounds, naphthoquinone amines, I (0.8; 0.6; 0.8), II (0.8; 0.6; 0.5) and the amine precursor, III (1.3; 0.3; 1.0) displayed potent anticancer activities. A tumor targeting drug delivery system was achieved by synthesizing the conjugate IV (1.4; 0.5; 1.1) of naphthoquinone-amine I and Biotin which also proved its potency. Finally, to introduce polyamine conjugate, spermidine was attached with 2-amidomethoxy-1,4-naphthoquinone. The naphthoquinone-spermidine conjugate V (1.2; 1.7; 1.7) also retained the activity. Thus, potent naphthoquinone amines were explored and Biotin/polyamine conjugate was developed as tumor targeting drug delivery system. In the part of experimental materials, we found many familiar compounds, such as N-Boc-1,6-Diaminohexane(cas: 51857-17-1Synthetic Route of C11H24N2O2)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Synthetic Route of C11H24N2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics