In 2022,Liu, Dan; Luo, Ling; Wang, Zhengxing; Ma, Xiaoyun; Gan, Xiuhai published an article in International Journal of Molecular Sciences. The title of the article was 《Design, Synthesis and Antifungal/Nematicidal Activity of Novel 1,2,4-Oxadiazole Derivatives Containing Amide Fragments》.Recommanded Product: Ethyl oxalyl monochloride The author mentioned the following in the article:
A series of novel 1,2,4-oxadiazole derivatives containing amide fragments I (R = C6H5, 4-CH3C6H4, 4-ClC6H4, etc.; R1 = 2-pyridyl, 2,4-Cl2C6H3, 2,4-F2C6H3 etc; n = 0, 1, 2) were designed and synthesized. Addnl., the bioassays revealed that the compound I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) demonstrated excellent antifungal activity against Sclerotinia sclerotiorum (S. sclerotiorum) in vitro, and the EC50 value of that was 2.9μg/mL, which is comparable with commonly used fungicides thifluzamide and fluopyram. Meanwhile, I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) demonstrated excellent curative and protective activity against S. sclerotiorum-infected cole in vivo. The SEM results showed that the hyphae of S. sclerotiorum treated with I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) became abnormally collapsed and shriveled, thereby inhibiting the growth of the hyphae. Furthermore, I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) exhibited favorable inhibition against the succinate dehydrogenase (SDH) of the S. sclerotiorum (IC50 = 12.5μg/mL), and the combination mode and binding ability between compound I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) and SDH were confirmed by mol. docking. In addition, compound (R = 4-ClC6H4; R1 = 2,4-F2C6H3; n = 1) showed excellent nematicidal activity against Meloidogyne incognita at 200μg/mL, the corrected mortality rate was 93.2%, which is higher than that of tioxazafen. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: Ethyl oxalyl monochloride
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics