Application of 403-33-8In 2021 ,《Cross-Dehydrogenative Coupling of Tetrahydroisoquinolines and 2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide: A New Synthetic Approach to α-Monofluoromethyl Tertiary Amines》 appeared in European Journal of Organic Chemistry. The author of the article were Huang, Bao-qin; Chen, Yuan; Zhang, Xue-jing; Yan, Ming. The article conveys some information:
A cross dehydrogenative coupling reaction of tetrahydroisoquinolines with 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide had been developed. CuBr/TBHP was identified as the best catalyst and oxidant. A variety of coupling products were obtained with good to excellent yields under mild reaction conditions. 1-Monofluoromethyl tetrahydroisoquinoline derivatives were prepared via a subsequent desulfonylation with sodium amalgam. This method provides a new synthetic approach to α-monofluoromethyl tertiary amines. A cross dehydrogenative coupling reaction of tetrahydroisoquinolines with 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide had been developed. CuBr/TBHP was identified as the best catalyst and oxidant. A variety of coupling products were obtained with good to excellent yields under mild reaction conditions. 1-Monofluoromethyl tetrahydroisoquinoline derivatives were prepared via a subsequent desulfonylation with sodium amalgam. This method provides a new synthetic approach to κDα-monofluoromethyl tertiary amines. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8
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