Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylateOn October 22, 2020 ,《First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters》 was published in Journal of Medicinal Chemistry. The article was written by Hernandez-Olmos, Victor; Heering, Jan; Planz, Viktoria; Liu, Ting; Kaps, Alexander; Rajkumar, Rinusha; Gramzow, Matthias; Kaiser, Astrid; Schubert-Zsilavecz, Manfred; Parnham, Michael J.; Windbergs, Maike; Steinhilber, Dieter; Proschak, Ewgenij. The article contains the following contents:
The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect stimulation of fibroblast activity in diabetic rats. CAY represents a very valuable starting point for the development of novel wound-healing promoters. In this work, the first structure-activity relationship study for CAY scaffold-based BLT2 agonists is presented. The newly prepared derivatives showed promising in vitro wound-healing activity. In the experimental materials used by the author, we found Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate)
Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics