Hall, Adrian’s team published research in Bioorganic & Medicinal Chemistry Letters in 2008 | CAS: 16982-21-1

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.COA of Formula: C4H7NO2S

In 2008,Hall, Adrian; Bit, Rino A.; Brown, Susan H.; Chowdhury, Anita; Giblin, Gerard M. P.; Hurst, David N.; Kilford, Ian R.; Lewell, Xiao; Naylor, Alan; Scoccitti, Tiziana published 《Novel methylene-linked heterocyclic EP1 receptor antagonists》.Bioorganic & Medicinal Chemistry Letters published the findings.COA of Formula: C4H7NO2S The information in the text is summarized as follows:

We describe the SAR, in terms of heterocyclic replacements, for a series of pyrazole EP1 receptor antagonists. This study led to the identification of several aromatic heterocyclic replacements for the pyrazole in the original compound Investigation of replacements for the methylene linker uncovered disparate SAR in the thiazole and pyridine series. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1COA of Formula: C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.COA of Formula: C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics