In 2009,Gowda, N. R. Thimme; Kavitha, C. V.; Chiruvella, Kishore K.; Joy, Omana; Rangappa, Kanchugarakoppal S.; Raghavan, Sathees C. published 《Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents》.Bioorganic & Medicinal Chemistry Letters published the findings.Related Products of 329-59-9 The information in the text is summarized as follows:
The synthesis and preliminary evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as potential chemotherapeutic agents are reported. In each case, the structures of the compounds were determined by FTIR, 1H NMR, and mass spectroscopy. Among the synthesized mols., Me 1-(4-methoxyphenethyl)-2-(4-fluoro-3-nitrophenyl)-1H-benzimidazole-5-carboxylate (I) induced maximum cell death in leukemic cells with an IC50 value of 3 μM. FACS anal. shows that the compound I induces S/G2 cell cycle arrest, which was further supported by the observed down regulation of CDK2, Cyclin B1, and PCNA. The observed downregulation of proapoptotic proteins, upregulation of antiapoptotic proteins, cleavage of PARP, and elevated levels of DNA strand breaks indicated the activation of apoptosis by I. These results suggest that I could be a potent anti-leukemic agent. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Related Products of 329-59-9)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Related Products of 329-59-9
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