In 2022,Gockel, Lukas M.; Pfeifer, Vladlena; Baltes, Fabian; Bachmaier, Rafael D.; Wagner, Karl G.; Bendas, Gerd; Guetschow, Michael; Sosic, Izidor; Steinebach, Christian published an article in Archiv der Pharmazie (Weinheim, Germany). The title of the article was 《Design, synthesis and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models》.Computed Properties of C11H24N2O2 The author mentioned the following in the article:
Three subgroups of enzalutamide-based PROTACs was presented in which only the exit vector was modified. By recruiting cereblon, the potent degradation of AR in lung cancer cells was demonstrated. Furthermore, the initial evaluation enabled the design of an optimized PROTAC with a rigid linker that degraded AR with a DC50 value in the nanomolar range. These results provide novel AR-directed PROTACs and a clear rationale for further investigating AR involvement in lung cancer models. After reading the article, we found that the author used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Computed Properties of C11H24N2O2)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Computed Properties of C11H24N2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics