Gianotti, Massimo; Corti, Corrado; Delle Fratte, Sonia; Di Fabio, Romano; Leslie, Colin P.; Pavone, Francesca; Piccoli, Laura; Stasi, Luigi; Wigglesworth, Mark J. published the artcile< Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders>, SDS of cas: 112-63-0, the main research area is imidazo benzazepine derivative preparation dual H1 5HT2A antagonist structure; sleep disorder imidazo benzazepine derivative.
A novel imidazobenzazepine template (5a) with potent dual H1/5-HT2A antagonist activity was identified. Application of a zwitterionic approach to this poorly selective and poorly developable starting point successfully delivered a class of high quality leads, 3-[4-(3-R1-2-R-5H-imidazo[1,2-b][2]benzazepin-11-yl)-1-piperazinyl]-2,2-dimethylpropanoic acids (e.g., 9, 19, 20, and 21), characterized by potent and balanced H1/5-HT2A receptor antagonist activities and good developability profiles.
Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT2A antagonists. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics