Recommanded Product: 4755-77-5In 2022 ,《Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis》 appeared in Research on Chemical Intermediates. The author of the article were Eya’ane Meva, Francois; Prior, Timothy J.; Evans, David J.; Shah, Sachin; Tamngwa, Cynthia Fake; Belengue, Herschelle Guyenne Lagrange; Mang, Roland Emmanuel; Munro, Justin; Qahash, Tarrick; Llinas, Manuel. The article conveys some information:
A novel 1,2,4-triazole intermediate 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid Et ester was prepared by the reaction of N’-aminopiridyne-2-carboximidamine and an excess monoethyl oxalyl chloride and screened for biol. activities. The compound was structurally characterized by NMR spectroscopy, elemental anal., IR spectroscopy, and single-crystal X-ray diffraction. Bioassays indicated that the compound exhibits potent anti-inflammation activity in vitro. An egg albumin denaturation assay to assess the anti-inflammatory effect of the synthesized compound showed a significant inhibition of protein with a maximum inhibition of 71.1% at the highest tested concentration (1000μg/mL) compared to 81.3% for Aspirin as standard drug. The antimalarial activity on the 3D7 P. falciparum strain was determined to be IC50 176μM and was obtained prior to connection with pharmacophoric groups. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5) was used in this study.
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 4755-77-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics