HPLC of Formula: 329-59-9In 2015 ,《Identification and optimization of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Ellard, John M.; Madin, Andrew; Philps, Oliver; Hopkin, Mark; Henderson, Scott; Birch, Louise; O’Connor, Desmond; Arai, Tohru; Takase, Kazuma; Morgan, Louise; Reynolds, David; Talma, Sonia; Howley, Eimear; Powney, Ben; Payne, Andrew H.; Hall, Adrian; Gartlon, Jane E.; Dawson, Lee A.; Castro, Luis; Atkinson, Peter J.. The article contains the following contents:
Herein the authors describe a series of tetrahydrobenzotriazoles as novel, potent metabotropic glutamate receptor subtype 5 (mGlu5) pos. allosteric modulators (PAMs). Exploration of the SAR surrounding the tetrahydrobenzotriazole core ultimately led to the identification of I as a potent mGlu5 PAM with a low maximal glutamate potency fold shift, acceptable in vitro DMPK parameters and in vivo PK profile and efficacy in the rat novel object recognition assay. As a result I was identified as a suitable compound for progression to in vivo safety evaluation. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9HPLC of Formula: 329-59-9)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.HPLC of Formula: 329-59-9
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics