Product Details of 623-47-2In 2019 ,《Design, Synthesis, Molecular Modeling Study, and Antimicrobial Activity of Some Novel Pyrano[2,3-b]pyridine and Pyrrolo[2,3-b]pyrano[2.3-d]pyridine Derivatives》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Elkanzi, Nadia A. A.; Bakr, Rania B.; Ghoneim, Amira A.. The article conveys some information:
Novel derivatives of pyrano[2,3-b]pyridine and pyrrolo[2,3-b]pyrano[2.3-d]pyridine were prepared, and their structures were elucidated by spectral and elemental analyses. The newly prepared candidates were evaluated for their antimicrobial activity against Candida sp., Aspergillus multi, Aspergillus niger, Escherichia coli, and Staphylococcus aureus. All the tested compounds revealed potent to moderate activity toward all tested microorganisms; especially, candidate I showed comparable antifungal activity as that showed by the standard drug ketoconazole toward Candida sp., and Et 4-methyl-1,7,8,9-tetrahydropyrano[2,3-b]pyrrolo[2,3-d]pyridine-3-carboxylate II was the most active compound against all the tested bacteria. Furthermore, the newly synthesized compounds are subjected to mol. docking study for the inhibition of the enzyme L-glutamine: D-fructose-6-phosphate amidotransferase [GlcN-6-P], which is a new target for antimicrobials to explain action mode of these target compounds as leads for discovering other antimicrobial agents. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Product Details of 623-47-2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Product Details of 623-47-2
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