In 2017,D’Errico, Stefano; Borbone, Nicola; Piccialli, Vincenzo; Di Gennaro, Elena; Zotti, Andrea; Budillon, Alfredo; Vitagliano, Carlo; Piccialli, Ilaria; Oliviero, Giorgia published 《Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold》.European Journal of Organic Chemistry published the findings.Quality Control of tert-Butyl (5-aminopentyl)carbamate The information in the text is summarized as follows:
Herein the authors report on the synthesis and evaluation of the preliminary antitumor properties of a small collection of Pt(II) complexes in which a cisplatin-like unit is tethered to 7-deazaadenosine through linear alkyl chains (from two to six C atoms) installed at the purine C6 position. The complexation was performed by exploiting the reactivity of the bidentate amino ligands (R)- and (S)-2,3-diaminopropanoic acids (DAPA) attached to the end of the alkyl chain spacer. By varying the length of the alkyl chain and the chirality of the DAPA moiety the authors obtained 10 novel nucleoside-Pt complexes, the anticancer properties of which were evaluated against the A549 and Cal27 human cancer cell lines. In the experiment, the researchers used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Quality Control of tert-Butyl (5-aminopentyl)carbamate)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Quality Control of tert-Butyl (5-aminopentyl)carbamate
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