HPLC of Formula: 51857-17-1In 2022 ,《Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold》 appeared in European Journal of Medicinal Chemistry. The author of the article were Chen, Jingjing; He, Huixin; Wei, Aihuan; Li, Yalei; Cheng, Gang; Qin, Hui; Zhong, Hanyue; Liu, Hongchun; Geng, Meiyu; Shen, Aijun; Hu, Youhong. The article conveys some information:
Novel pyrrolopyridone BET degraders were designed and synthesized based on the binding mode between the pyrrolopyridone BET inhibitor with the BRD4 protein. The potent degraders on MV-4-11 cells were discovered through structure-activity relationship study. Modification of warhead on pyrrolopyridone BET degraded significantly regulates BRD4 isoform (long and short) protein degradation, which induced differential cell cycle arrest and apoptosis on MV-4-11 cells. Docking study revealed that the fine structural modification of BET degraders might bind with the BD domain of BRD4 protein to engaged various surface areas that bind with CRBN. In the part of experimental materials, we found many familiar compounds, such as N-Boc-1,6-Diaminohexane(cas: 51857-17-1HPLC of Formula: 51857-17-1)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.HPLC of Formula: 51857-17-1
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