Baldwin, Aaron F.; Caporello, Michaella A.; Chen, Guoyong; Goetz, Adam E.; Hu, Weifeng; Jin, Chengfeng; Knopf, Kevin M.; Li, Zhifeng; Lu, Cuong V.; Monfette, Sebastien; Puchlopek-Dermenci, Angela L. A.; Shi, Feng published their research in Organic Process Research & Development in 2021. The article was titled 《Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation》.Related Products of 4248-19-5 The article contains the following contents:
We describe a scalable method for preparing an aminopyrazole building block using copper-catalyzed amidation with acetamide as an ammonia surrogate (4-bromo-1-methyl-1H-pyrazole + acetamide →→ 1-methyl-1H-pyrazol-4-amine hydrochloride). This procedure provides an alternative to the standard nitration/reduction sequence and avoids energetic intermediates, specialized hydrogenation equipment, and potentially genotoxic impurities that arise from nitro reduction The chem. has been successfully scaled to produce >50 kg of the target compound and demonstrate the viability of this alternative route. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Related Products of 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 4248-19-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics