《Late-stage peptide macrocyclization by palladium-catalyzed site-selective C-H olefination of tryptophan》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Bai, Zengbing; Cai, Chuangxu; Sheng, Wangjian; Ren, Yuxiang; Wang, Huan. Related Products of 7524-52-9 The article mentions the following:
Transition-metal-catalyzed C-H activation has shown potential in the functionalization of peptides with expanded structural diversity. Herein, the development of late-stage peptide macrocyclization methods by palladium-catalyzed site-selective C(sp2)-H olefination of tryptophan residues at the C2 and C4 positions is reported. This strategy utilizes the peptide backbone as endogenous directing groups and provides access to peptide macrocycles with unique Trp-alkene crosslinks. In the experiment, the researchers used H-Trp-OMe.HCl(cas: 7524-52-9Related Products of 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Related Products of 7524-52-9
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