Mohamed, Yasser Mahmoud A.; Attia, Yasser A. published the artcile< The influence of ultrasonic irradiation on catalytic performance of ZnO nanoparticles toward the synthesis of chiral 1-substituted-1H-tetrazole derivatives from α-amino acid ethyl esters>, Synthetic Route of 2743-40-0, the main research area is tetrazole preparation green chem enantioselective ultrasonic irradiation; amino acid ethyl ester triethyl orthoformate zinc oxide nanocatalyst.
In this work, a simple and greener protocol for the synthesis of 1-substituted 1H-tetrazole derived I (R = H, 2-methylpropyl, benzyl, 1H-indol-2-ylmethyl, etc.) from α-amino acid Et esters CH3CH2OC(O)CH(R)NH2.HCl was demonstrated in the presence of zinc oxide nanoparticles (ZnO NPs) under conventional conditions, with heating (at 60 and 80°C and under reflux) compared with ultrasonic. The effect of solvent was investigated to reveal that the solvent system CH3CN/H2O was optimum to obtain 1-substituted 1H-tetrazole I in high yield. In addition, the effect of irradiation power was studied, which showed that the yield of the reaction was improved at 200 W and the reaction time was shortened to be 30 min. Also, an improvement in the rate of the reaction and the yield of the products was observed when reactions were carried out under sonication conditions in the presence of ZnO NPs compared with conventional methods using various zinc salts as catalysts. The yields of tetrazole compounds I under sonication were determined (88-96%). Furthermore, the investigated heterogeneous catalytic system was recycled and reused for five runs with significant production of tetrazole I as a model target compound in excellent yields at each reaction cycle. In general, the investigated synthetic strategy for the heterocyclization of α-amino acid Et ester derivatives to 1-substituted 1H-tetrazoles I was in agreement with the green chem. point of view.
Applied Organometallic Chemistry published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Synthetic Route of 2743-40-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics