Heaysman, Clare L.; Phillips, Gary J.; Lloyd, Andrew W.; Lewis, Andrew L. published the artcile< Synthesis and characterization of cationic quaternary ammonium-modified polyvinyl alcohol hydrogel beads as a drug delivery embolization system>, COA of Formula: C19H34O2, the main research area is cationic quaternary ammonium polyvinyl alc hydrogel bead drug delivery.
To extend the platform of clin. utilized chemoembolic agents based on ion-exchange systems to support the delivery of anionic drugs, a series of PVA-based beads was produced with different levels of (3-acrylamidopropyl)trimethylammonium chloride (APTA) in their formulation. The beads were characterized to confirm composition and the effect of formulation variation on phys. properties was assessed. Suspension polymerization was shown to successfully produce uniformly spherical copolymer beads with APTA content up to 60%. Equilibrium water content and resistance to compression both increased with increasing APTA content in the formulation. Confocal laser scanning microscopy was used with model drugs to demonstrate that by increasing APTA content, compounds between the mol. weight range 70-250 kDa could permeate the microsphere structures. Interaction with anionic drugs was modelled using multivalent dyes. Dyes with multi-binding sites had increased interaction with the polymer, slowing the release and also demonstrating a reduced rate of elution from beads with higher charge d. The model drug release studies demonstrate that these systems can be engineered for different potential anionic drugs for local therapeutic delivery in the clinic.
Journal of Materials Science: Materials in Medicine published new progress about Electric charge. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics