In 2022,Zou, Miancheng; Zhao, Pengkun; Fan, Jilin; Gostl, Robert; Herrmann, Andreas published an article in Journal of Polymer Science (Hoboken, NJ, United States). The title of the article was 《Microgels as drug carriers for sonopharmacology》.Computed Properties of C5H6O2 The author mentioned the following in the article:
The ultrasound-induced cleavage of covalent and non-covalent bonds to activate drugs (sonopharmacol.) is a promising concept to gain control over the action of active pharmaceutical ingredients by an external trigger. Previously, linear polymer architectures bearing drug payloads were exploited for drug release by using the principles of polymer mechanochem. In this work, the carrier design is altered by the polymer topol. to improve the ultrasound-triggered release of covalently anchored drugs from polymer scaffolds. We use microgels crosslinked by mechanoresponsive disulfides and copolymerized with Diels-Alder adducts of furylated payload mols. and acetylenedicarboxylate. Force-induced thiol formation induces a Michael-type addition liberating the payload from the microgels. The use of microgels significantly reduces sonication times compared to linear polymer chains and shields the cargo efficiently from non-triggered activation using ultrasound that produces inertial cavitation at a frequency of 20 kHz as model condition. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Computed Properties of C5H6O2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Computed Properties of C5H6O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics