Zhang, Wande; Wei, Shiqiang; Wang, Wenyao; Qu, Jingping; Wang, Baomin published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements》.Product Details of 4949-44-4 The article contains the following contents:
An organocatalytic asym. process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives I (R1 = Bn, Me, 1-naphthylmethyl, etc.; R2 = Et, Ph, 2-thienyl, etc.; R3 = H, Br; Ar = Ph, 2-bromophenyl, 2-thienyl, etc.) bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20 : 1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Product Details of 4949-44-4)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 4949-44-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics