Westaway, Susan M.; Brown, Samantha L.; Conway, Elizabeth; Heightman, Tom D.; Johnson, Christopher N.; Lapsley, Kate; Macdonald, Gregor J.; MacPherson, David T.; Mitchell, Darren J.; Myatt, James W.; Seal, Jon T.; Stanway, Steven J.; Stemp, Geoffrey; Thompson, Mervyn; Celestini, Paolo; Colombo, Andrea; Consonni, Alessandra; Gagliardi, Stefania; Riccaboni, Mauro; Ronzoni, Silvano; Briggs, Michael A.; Matthews, Kim L.; Stevens, Alexander J.; Bolton, Victoria J.; Boyfield, Izzy; Jarvie, Emma M.; Stratton, Sharon C.; Sanger, Gareth J. published their research in Bioorganic & Medicinal Chemistry Letters on December 15 ,2008. The article was titled 《The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor》.Application of 144291-47-4 The article contains the following contents:
Optimization of urea (5), identified from high throughput screening and subsequent array chem., has resulted in the identification of pyridine carboxamide (33, I) which is a potent motilin receptor agonist possessing favorable physicochem. and ADME profiles. Compound (33) has demonstrated prokinetic-like activity both in vitro and in vivo in the rabbit and therefore represents a promising novel small mol. motilin receptor agonist for further evaluation as a gastroprokinetic agent. In the experimental materials used by the author, we found Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Application of 144291-47-4)
Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Application of 144291-47-4 Polyesters are important plastics, with monomers linked by ester moieties.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics