In 2022,Wang, Wen-Tao; Zhang, Sen; Tao, Ling-Fei; Pan, Zi-Qi; Qian, Linghui; Liao, Jia-Yu published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Cooperative catalysis-enabled C-N bond cleavage of biaryl lactams with activated isocyanides》.Computed Properties of C5H11NO2 The author mentioned the following in the article:
The catalytic reaction of biaryl lactams with activated isocyanides was reported for the first time. By employing a cooperative catalytic system, oxazole-containing axially chiral biaryl anilines, e.g., I were obtained in high yields with excellent enantioselectivities. The key to the success was in the atroposelective amide C-N bond cleavage with activated isocyanides. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Computed Properties of C5H11NO2)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Computed Properties of C5H11NO2
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