In 2022,Wang, Guangzhu; Shen, Chaoren; Ren, Xinyi; Dong, Kaiwu published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of N-(2-iodo-aryl) acrylamide》.Application In Synthesis of Diethyl 2-methylmalonate The author mentioned the following in the article:
A Ni/(S,S)-BDPP-catalyzed intramol. Heck cyclization of N-(2-iodo-aryl)acrylamides with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. By utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asym. alkene arylcyanation. The experimental part of the paper was very detailed, including the reaction process of Diethyl 2-methylmalonate(cas: 609-08-5Application In Synthesis of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Application In Synthesis of Diethyl 2-methylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics