In 2010,Tyagarajan, Sriram; Chakravarty, Prasun K.; Zhou, Bishan; Fisher, Michael H.; Wyvratt, Mathew J.; Lyons, Kathy; Klatt, Tracy; Li, Xiaohua; Kumar, Sanjeev; Williams, Brande; Felix, John; Priest, Birgit T.; Brochu, Richard M.; Warren, Vivien; Smith, McHardy; Garcia, Maria; Kaczorowski, Gregory J.; Martin, William J.; Abbadie, Catherine; McGowan, Erin; Jochnowitz, Nina; Parsons, William H. published 《Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers》.Bioorganic & Medicinal Chemistry Letters published the findings.Electric Literature of C4H7NO2S The information in the text is summarized as follows:
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low mol. weight biaryl substituted imidazole, e.g. I, oxazole, e.g. II, and thiazole, e.g. III, carboxamides were identified with good in vitro and in vivo potency. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Electric Literature of C4H7NO2S)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C4H7NO2S
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics