Tharra, Prabhakara R.; Mikhaylov, Andrey A.; Svejkar, Jiri; Gysin, Marina; Hobbie, Sven N.; Svenda, Jakub published an article in 2022. The article was titled 《Short Synthesis of (+)-Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis》, and you may find the article in Angewandte Chemie, International Edition.Application of 4949-44-4 The information in the text is summarized as follows:
We report a concise synthesis of the naturally occurring protein synthesis inhibitor (+)-actinobolin. The densely functionalized and stereochem. complex mol. structure of (+)-actinobolin was assembled from (-)-quinic acid, L-threonine, and L-alanine as the principal components. Our route is based around a convergent strategy that features conjugate addition of an α-amino radical in the key fragment-coupling step. The dramatically simplified synthesis of (+)-actinobolin proceeding in 9 steps with 18% overall yield has practical implications for analog preparation, as demonstrated herein.Ethyl 3-oxopentanoate(cas: 4949-44-4Application of 4949-44-4) was used in this study.
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application of 4949-44-4
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