Sun, Zhongwen; Chen, Lijun; Qiu, Kaixiong; Liu, Bo; Li, Hongtao; Yu, Fang published an article in 2022. The article was titled 《Enantioselective Peroxidation of C-alkynyl imines enabled by chiral BINOL calcium phosphate》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Formula: C5H11NO2 The information in the text is summarized as follows:
Herein, a catalytic enantioselective addition of C-alkynyl imines, generated in-situ from N,O-acetals R1CCCH(OEt)NHR2 (R1 = Me3Si, Ph, 2-ClC6H4, 1-naphthyl, 2-thienyl, 3-pyridinyl, etc., R2 = Boc; R1 = Ph, R2 = Teoc, PhCO, Fmoc, Cbz) with hydroperoxides R3OOH (R3 = t-Bu, PhCH2, EtMe2, etc.) catalyzed by chiral BINOL calcium phosphate, affording a broad range of enantioenriched α-peroxy propargylamines (R)-R1CCCH(OOR3)NHR2 in good yields (80-99%) with high enantioselectivities (up to 94% ee) is reported. The protocol is characterized by mild conditions, easy accessibility and good practicability. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Formula: C5H11NO2)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C5H11NO2
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