The author of 《A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles》 were Stress, Cedric J.; Sauter, Basilius; Schneider, Lukas A.; Sharpe, Timothy; Gillingham, Dennis. And the article was published in Angewandte Chemie, International Edition in 2019. Product Details of 67877-95-6 The author mentioned the following in the article:
Here the authors show a seven-step chem. synthesis of a DNA-encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide-polyketide natural products, the library was designed to incorporate rich backbone diversity. Achieving this diversity, however, comes at the cost of the custom synthesis of bifunctional building block libraries. This study outlines the importance of careful retrosynthetic design in DNA-encoded libraries, while revealing areas where new DNA synthetic methods are needed. In the part of experimental materials, we found many familiar compounds, such as H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Product Details of 67877-95-6)
H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 67877-95-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics